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2022 Pharma MOA Demoreel

We are excited to share our latest demo reel, highlighting some of the stunning 3D mechanism of action animations we have recently created for our clients in the pharmaceutical and biotech space. This reel encompasses why the team here at Scientific Animations continues to be at the forefront of medical animation and science visualization over the last 15 years.

2021 Medical Device Demoreel

We are excited to share our latest demo reel, highlighting some of the stunning 3D medical device animations we have recently created for our clients. This reel encompasses why the team here at Scientific Animations continues to be at the forefront of medical animation and science visualization over the last 15 years.

The immune system fights cancer

This mechanism of action (MOA) animation was created as a general overview to be a patient-facing piece on the website for a prominent cancer treatment organization. It details the use of immunotherapy in the treatment of cancer.

Pulmonary Embolism Treatment System

This animation highlights a minimally invasive system for dissolving thrombus using ultrasonic technology. This revolutionary treatment uses ultrasonic waves in combination with clot-dissolving drugs to dissolve the clot, reducing the risk of both pulmonary embolism and long-term side effects. This stunning video illustration exhibits ground-breaking technology that can be used for marketing and education.

Cancer Radiotherapy System

This piece was created to showcase a game-changing approach to cancer treatment. It highlights a method of radiation which utilizes the cancer itself to guide its delivery. By combining radiotherapy and PET-CT, this is the only machine with the potential to use disease-specific tracers to see and treat hard-to-find tumors. This animation walks you through the inner-workings of the system and can be used for both marketing and education.

Microcatheter Showcase

This animation spotlights a microcatheter that is engineered with a first of its kind, 175cm length, which is ideal for radial access and offers interventionalists the opportunity to get closer to intended targets without compromising flow rates or embolic choices. Designed with a balance of pushability and flexibility, this microcatheter offers enhanced traceability through tortuous anatomy. An innovative video such as this is a significant marketing tool and a valuable educational component.

Heart Failure Implant Therapy

This new class of therapy is the first to repair the left ventricle and directly target the cause of heart failure. Using a minimally invasive, non-surgical approach, the implant is placed into the left ventricular wall, just below the mitral valve. Once placed, it is then cinched tight and secured in place. Developed to reduce the size of the left ventricle, as well as support and strengthen the heart wall, this revolutionary implant likely allows for faster recovery times compared to open-heart procedures. This stunning animation highlights the features of the device as well as step-by-step usage and is suitable for both marketing and education.

Journey of a Cell

Augmenting eye drainage to reduce IOP

Depicting a novel procedure for lowering intraocular pressure, this eye animation required a beautiful cut section of the eye. We chose to show this as a soft illustration, similar to a colorized look of a medical textbook illustration. This was then contrast by showing the procedure in the Shlemm's canal with full VFX in a high contrast 3D environment. An example of versatility in animation, we have created VR versions of this also.

Using soundwaves in thrombolysis

A novel therapy that ingeniously uses sound to increase effectiveness of thrombosis removal. The device animation is heavy on VFX (visual effects) to show how acoustic streaming helps enhance drug deliverability. Look for the glowing drug particles in the blood flow scene; this is one common way we can highlight important elements of the visual communication while still showing full sections of anatomy

Drug delivery coated balloons

Devices that were ordinary in past procedures are no longer. We are seeing smarter equipmement, like drug delivering wound healing dressing, drug eluting stents and also, as in this animation, drug coated balloons. This procedure uses drug coated balloons to treat peripheral artery disease. Look for the scene where the balloon approaches the camera from above. We were inspired by a combination of a bullet train arriving in the station and a dirigible coming in to land.

Using acoustic waves to enhance erections

Sensitivity is key when you are working in the area of Women's or Men's health. This innovative solution to increasing blood flow to enable an erection, utilises a combination of fiberglass looks, extreme closeups, and cross sections to handle the topic maturely, and medically.

2021 Pharma MOA Demoreel

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Medical Devices / Procedures

Ventricular repair in heart failure

This Transcatheter Ventricular Enhancement System improves cardiac function by restoring the shape, volume, and resulting performance of the left ventricle (LV) in ischemic heart failure patients. It details the placement and delivery of the system by showing some great cutouts of our beating heart model.

Mitral Valve Replacement System

This animation showcases a mitral valve replacement system used for treating mitral valve insufficiencies and defects. Educational in its purpose, this video demonstrates how the device is accessed, implanted and secured. It also features animation of the heart during the process.

Catheter Based Glaucoma Treatment

This animation demonstrates an illuminated micro-catheter instrument designed for minimally invasive glaucoma surgery. It succinctly exhibits the benefits of this device and describes its methodology of use. This video can be used both educationally and for marketing purposes.

Embolic Ischemic Stroke Protection Device Animation

This piece was created to showcase a revolutionary embolic protection device which is used to capture and remove thrombus debris while performing transcatheter aortic valve replacement procedures. This device can protect against periprocedural stroke and is the only percutaneously delivered, dual-filter embolic protection system that takes only a few moments to be placed and has no known safety risks. This animation is a straight forward marketing video which highlights the product and its benefits.

Rapid Pathogen Detection System

This piece was created to showcase a revolutionary automated pathogen detection system that is able to quickly identify up to 22 pathogens at once and deliver results in about an hour. This easy to use, straight-forward system can be utilized on site by the individual taking the sample, with no molecular expertise required. This device features an open-access system which allows researchers to customize their testing. This stunning animation exhibits ground-breaking technology that walks you through the inner-workings of the system and can be used for both marketing and education.

Intervascular Lithotripsy System

This impressive video presentation showcases an Intervascular Lithotripsy (IVL) catheter that delivers optimized energy for the treatment of cardiovascular calcium while minimizing trauma, optimizing outcomes and simplifying procedures. Utilizing an electrical discharge from the emitters, the fluid is vaporized within the balloon creating a rapidly expanding & collapsing bubble that generates sonic pressure waves. The waves travel through soft vascular tissue, selectively cracking intimal & medial calcium within the vessel wall. This stunning animation can be used in education when it walks you through the steps of its use or for marketing purposes.

Temporary Pacing System

This revolutionary, implantable temporary pacing system is designed to leave the heart and vascular system untouched while using a proprietary parasternal approach, into the extracardiac tissue between the ribs and pericardium. Engineered to provide reliable pacing support without the discomfort, risk, and limitations of traditional methods, this pacing system is created to rapidly and reliably restore cardiac rhythm. Highlighting the mechanism of action, this video is a great example of how animation can be used for marketing or education.

Vascular Foot Ulcer Detection Device

This stunning animation highlights a groundbreaking imaging system that is designed to assist clinicians in identifying potential compromised circulation that may indicate that a patient is at risk for an ulceration or infection. Utilizing a revolutionary no contact, noninvasive microvascular assessment tool, this proprietary optical imaging technique provides insight into the delivery and extraction of oxygen to tissue. This video is an excellent example of how animation can be used in both education and marketing.

Radiotherapy for the Treatment of Cancer

This piece was created to showcase a game-changing approach to cancer treatment. It highlights a radiation method that utilizes cancer to guide its delivery. By combining radiotherapy and PET-CT, this is the only machine with the potential to use disease-specific tracers to see and treat hard-to-find tumors. This animation walks you through the system's inner workings and can be used for marketing and education.

Drug delivery coated balloons

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Oncology / Immunotherapy

The immune system fights cancer

MS Oral Immunomodulator Showcase

"This animation highlights an oral immunomodulator that is indicated for the treatment of people with relapsing forms of MS. Research supports that this drug inhibits the proliferation of activated T & B lymphocytes in the periphery. Through this cytostatic effect, this drug appears to limit the number of auto reactive lymphocytes that can contribute to MS disease activity. This piece is broad marketing illustration which spotlights the product, it’s inner-workings and effectiveness. "

Cancer Immunotherapy Showcase

This piece highlights a revolutionary cancer immunotherapy device that utilizes a three-step process to deliver a novel therapeutic treatment. This three-step process includes placement of a probe into a targeted tumor to disrupt cancer cell membranes in a way that does not damage the complex antigen structures, then an injection of a proprietary immunotherapy formulation is placed into the treatment area. These steps enable the immune system to recognize the cancer and create an autologous therapeutic vaccine which is derived from the patient’s own tumor cell antigens. This vaccine then travels throughout the body to attack the cancer. This video is an outstanding example of how animation can be used in both education and marketing.

Bispecific Antibodies for Oncology Treatment

This contemporary piece focuses on a next-generation approach to immuno-oncology, which is designed to enable more efficient production of bispecific antibodies that can engage multiple targets simultaneously, enhancing the power of the immune system to fight disease. The bispecific antibodies have two separate arms built into one antibody. One arm binds to a T-cell while the other binds to specific targets on different types of tumor cells. The platform uses this process to activate and localize cancer-fighting immune cells where they’re needed to attack the disease. This video is a stunning example of how animation can be used in both education and marketing.

Adult Bacterial Pneumonia Drug Treatment Mechanism of Action Showcase

This next-generation pleuromutilin antibacterial is indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP). This new drug is a systemic, empiric pleuromutilin antibiotic with activity against specific Gram-positive, Gram-negative, and other respiratory bacteria. It has a a chemical structure distinct from existing classes of antibiotics used in CABP and adverse reactions were generally mild to moderate regardless of how it was administered (oral or IV). This stunning animation highlights ground-breaking technology that can be used for marketing and education.

Cancer Radiotherapy System

In House MRNA Vaccine

This animation demonstrates the mechanism of action of Messenger RNA based vaccines for COVID-19 (SARs-CoV-2) from companies such as Pfizer-BioNTech, Moderna, and Arcturus Therapeutics.

Nephropathy Targeting Therapeutic

This mechanism of action animation of about proprietary monoclonal antibody therapeutic targeting APRIL, which is being evaluated for the treatment of IgA nephropathy. Preclinical studies have demonstrated that BION-1301 binds to a specifically defined epitope on APRIL, resulting in complete blockade of APRIL-induced receptor activation. This academic piece is an example of how animation can be used for education and marketing purposes.

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Pharma / MOA / Genomics

The immune system fights cancer

What happens in a migraine?

This animation was created to showcase the importance of migraine treatment. It highlights the severe symptoms of a migraine headache and the effects it can have on an individual. This piece is a great example of how animation can be used for education and marketing.

Who doesn’t want great skin?

This piece highlights a skincare product that helps reduce wrinkles and increases skin density, resulting in a more youthful looking skin. By combining two different peptides, this skincare treatment visibly reduces wrinkles and significantly improves skin density. This video is a great example of how animation can be used for education and marketing.

Hyperosmolarity Diagnostic Showcase

The video demonstrates the vital importance of maintaining tear hyperosmolarity. Derangement in osmolarity can, as a consequence, lead to aberrations in vision. The video is a remarkable representation of the changes that occur on a cellular level and is an effective marketing and education tool.

Neuromuscular Blockade Reversal Agent Showcase

This educational animation was created to showcase an agent that reverses neuromuscular blockage from rocuronium and vecuronium in general anesthesia. This piece is educational in that it breaks down the safety precautions and risks but also does a great marketing job by visually highlighting how the product works.

Melatonin Drug Mechanism of Action Showcase

This animation highlights a melatonin product that utilizes a breakthrough drug delivery system which offers continuous release and absorption technology that mimics the body’s own release of melatonin during the sleep cycle. Created without alcohol, narcotics, sedatives or antihistamines, this melatonin sleep aid doesn’t cause morning drowsiness, is not associated with dependence and will deliver up to 7 hours of deep and restorative REM sleep. This innovative video illustration exhibits technology that can be used for marketing and education.

Bispecific Antibodies for Oncology Treatment

In House MRNA Vaccine

This animation demonstrates the mechanism of action of Messenger RNA based vaccines for COVID-19 (SARs-CoV-2) from companies such as Pfizer-BioNTech, Moderna, and Arcturus Therapeutics.

Schizophrenia mechanism of disease

This mechanism of action animation explains the possible role of seratonin and dopamine in the cause and possible treatment of schizophrenia.

Potential to treat resistant seizures

This mechanism of action animation about Ganaxolone is a GABAA receptor modulator that acts by regulating brain activity. Ganaxolone binds to one of the receptor subtypes, the GABAA receptor. When this receptor is activated, it increases the movement of chloride ions through a pore on the cell surface. These binding sites, including the extrasynaptic GABAA receptor, may also be important in treating status epilepticus and other brain disorders. This academic piece is an example of how animation can be used for education and marketing purposes.

Nephropathy Targeting Therapeutic

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Cardiology

Ventricular repair in heart failure

Mitral Valve Replacement System

Temporary Pacing System

Heart Failure Implant Therapy

Heart Failure Implanted Device CCM Therapy – Patient Video

This video describes how CCM therapy can benefit patients with HF who are not responding to conventional (medical) therapy, along with what to expect and what to do to obtain access to Cardiac Contractility Modulation Therapy. Patient Education

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Vascular Access

Biopsy Device Showcase

This piece showcases an innovative biopsy system that comes in several lengths that can offer increased patient comfort and alleviate anxiety. This is a good example of our capability of creating a device-based animation highlighting the features and benefits of product technology.

Vascular Hypertension Treatment Device

This animation showcases an innovative vascular device that creates a connection between the external iliac artery and the external iliac vein. The procedure utilizing this device is percutaneous, uses only local anesthesia and can be done in an angiography suite. This piece is both marketing and educational in nature as it highlights the device as well as discusses the process of employing it.

Small Molecule Coagulant Mechanism of Action

This piece highlights an innovative, potent and selective small-molecule inhibitor which offers the potential of thrombosis prevention without the bleeding liabilities which exist for all current treatment options. By selectively inhibiting the activation of the intrinsic pathways and without impacting normal hemostasis through the extrinsic pathway, this targeted anticoagulation will not only prevent major bleeding events but will also reduce healthcare costs. This video is an outstanding example of how animation can be used in both education and marketing.

Intervascular Lithotripsy System

Vascular Foot Ulcer Detection Device

Microcatheter Showcase

Using soundwaves in thrombolysis

Drug delivery coated balloons

Using acoustic waves to enhance erections

Achieving hemostasis faster during vascular surgery

This vascular sealant example shows our ability to show different types of texture. The toothpaste or gel like look for this product is the result of years or experience animating different medical products.

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Gastrointestinal / Renal / Pulmonology / OB-GYN / Urology

Uterine Tubal Patency Device

Depicting the qualities and advantages of a uterine tubal patency device. This product showcase animation has some great pelvic, uterine, and tubal anatomy models.

Surgical Site Infection Prevention Guard

This animation describes a revolutionary technology that decreases incidents of surgical infections. By walking through the steps of how the device works, this piece details the use and importance of a surgical site guard against surgical infections.

Lung – Pulmonary Emphysema Treatment Device

This animation spotlights a revolutionary pulmonary emphysema treatment device that delivers personalized, targeted treatment to the affected area and gives the patient increased breathing and lung function, a better quality of life and is not associated with long term complications normally associated with implants. This piece contains some great visuals of product shots as well as pulmonary anatomy.

Gastric Retrieval Device Showcase

This piece highlights a revolutionary gastric retrieval device that is safe, secure and effectively retrieves a variety of foreign bodies endoscopically. This device utilizes both grasping and suction to retrieve food bolus impactions, foreign bodies and excised tissue such as large polyps. This is a good example of our capability of creating a device based animation spotlighting the features and benefits of a product technology.

Biopolar RF Catheter for GI Tract

This animation showcases a bipolar radio frequency (rf) catheter that provides partial or complete ablation of malignant or benign tissue in the pancreatic and biliary tracts. This catheter can also be used to clear biliary metal stents that become blocked by overgrown tissue by conducting ablation then passing through an inflated balloon that performs debridement to clear away the dead tissue. This state of the art video illustration exhibits ground-breaking technology that can be used for marketing and education.

Percutaneous Aspiration of Pleural Effusion Showcase

This animation highlights a small catheter that is indicated for the percutaneous aspiration of pleural effusion. This catheter is unique in that it is smaller, and has a more reliable insertion system that requires less force. It is flexible and designed to safely remain in place while post drainage checks are performed. This innovative video illustration exhibits technology that can be used for marketing and education.

Sacral Neuromodulation Device

This clinically proven solution is designed to help people regain urinary and bowel control through either constant current stimulation or voltage controlled stimulation. A small implantable neurostimulator is connected to a lead that is placed adjacent to a sacral root and the lead delivers electrical pulses which modulate the activity of the sacral nerve. For people with over active bladder, non-obstructive urinary retention, or bowel incontinence there is thought to be abnormal communication between the bladder and the brain. Sacral Neuromodulation is thought to work through somatic afferents in the sacral nerve which modulates spinal and brain control of the bladder and bowel by restoring normal communication between the brain and the bladder and bowel. This stunning animation highlights the features of the device and is suitable for both marketing and education.

Sampling tissue from the billiary tree

Sampling the billiary tree requires a sophisticated ERCP device. In this 3D animation we depicted how such a sample can be collected with a new device that has an innovative mechanism to keep the sampling jaws closed during extraction.

Using acoustic waves to enhance erections

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Neurology / Ophthalmology

What happens in a migraine?

Advanced Lens Implantation System

This animation exhibits an advanced lens implantation technology that has many unique features including four separate optic designs, ease of implantation as well as procedural reversibility. This video illustration exhibits ground-breaking technology that can be used for marketing and education.

Catheter Based Glaucoma Treatment

Hyperosmolarity Diagnostic Showcase

Ophthalmology Refractive Capsule Showcase

This animation features a state-of-the-art interocular capsule that can treat cataracts, glaucoma and macular degeneration as well as provide a platform for the future integration of virtual, augmented and mixed reality. This high-tech, 3D implant device features an open capsular bag, true refractive lens and maintains open space for drug delivery, biometric sensors and additional lens technologies. It is designed to hold additional lens during primary surgery or in the future for upgrades. This piece is a straight forward marketing video illustration which highlights the product and its benefits.

First-Line Glaucoma Therapy Showcase

This animation showcases a first-line therapy for the treatment of glaucoma. This advanced, non-thermal nanosecond laser treatment can achieve reductions in IOP as effectively as medication, without the associated side effects. This piece exhibits ground-breaking technology that can be used for marketing and education.

Schizophrenia mechanism of disease

This mechanism of action animation explains the possible role of seratonin and dopamine in the cause and possible treatment of schizophrenia.

Potential to treat resistant seizures

Augmenting eye drainage to reduce IOP

Laser treatment to vaporize floaters

For some, eye floaters are annoying. For others they are dehabillitating. This animation for a laser treatment for vitreous floaters showcases not only the anatomy, but also the device. In house we have a technical term for the qualitative standard that these device showcases should live up to. It's called GETE - good enough to eat ! Look for the device shot and let us know if it's GETE.

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Dermatology / Cosmetics / Orthopedics / Spine

Who doesn’t want great skin?

Bone Graft Substitution

This animation highlights an innovative bone graft substitute that promotes bone repair, fusion and replacement with the use of partially demineralized allograft bone and adipose stem cells. This piece is an example of an effective use of animation for education and marketing purposes.

Knee Replacement Technology Animation

This educational animation highlights the use of an innovative knee replacement device. This piece showcases advance coatings, improved kinematics as well as variable mechanisms for replacement and can be a valuable marketing and educational tool.

Treatment for Dupuytren’s Contracture

This animation spotlights a treatment for Dupuytren’s Contracture by using an injection containing a mixture of enzymes to disrupt types I and II collagen found in the tissue cords. This treatment is effective without damaging nerves, arteries, or large veins containing type IV collagen. This video is a great example of how animation can be used for education and marketing.

Mechanism of Disease for Dupuytren’s Contracture

This animation spotlights the mechanism of disease for Dupuytren’s Contracture. It effectively explains how the condition affects a layer of tissue that lies under the skin of your palm by forming knots of tissue that eventually creates a thick cord that can pull one or more fingers into a bent position. This video is geared towards education and is more academic in nature.

Placental Allograft Membrane Showcase

This animation highlights a next generation, tri-layer allograft consisting of amnion-chorion-amnion layers that aids in creating an environment to help close complex, soft tissue wounds. The proprietary processing technology preserves the inherent growth factors, cytokines and extracellular matrix (ECM) found in native placental tissue, which allows it to be robust, flexible and non-side specific. Innovative video showcases such as this, are a significant marketing element and a valuable educational component.

Knee Replacement

This set of 3D animations for an autologous cellularized scaffold product used for knee repair procedures has some beautiful anatomical visuals of the muscles and ligaments supporting the knee.

Silver wound healing device Mode of Action

This 3D animation explains how a silver wound healing antimicrobial dressing works. Silver ions have an antimicrobial effect which accelerates the wound healing process. This is a great example of an animation used towards general education and marketing.

Spinal rods that grow with your child

Childhood scoliosis treatment has progressed far beyond traditional braces. Sophisticated surgical options are now available, including, rods that grow along with children. This animation explains the concept of growing rods through a mix of animation and images. and of course, special effects.

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Medical Equipment / Radiology / Imaging

Guided neurosurgery

This animation showcases a stereotactic neurosurgery device that offers highly accurate access to a patients brain with a four-step procedural plan. This piece outlines the four steps: Step one: the surgeon plans his trajectory. Step two: the device is mounted. Step three: a CT scan is fused with a pre-op MRI scan. Step four: the surgeon operates using the small, frameless device. This video is a great example of how animation can be used for education and marketing.

First-Line Glaucoma Therapy Showcase

Rapid Pathogen Detection System

Cancer Radiotherapy System

Sacral Neuromodulation Device

Journey of a Cell

Cell Growth Equipment VR Experience

This VR animation highlights the components of an integrated cell storage & propagation system. The video showcases a variety of different components involved with cell storage, viability, propagation, harvest and monitoring. It essentially exhibits ground-breaking technology as an all-encompassing system focusing on multiple products which can be used for marketing and education.

Radiotherapy for the Treatment of Cancer

Laser treatment to vaporize floaters

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Dental / Consumer Products / Video FX

Non Alcoholic Fatty Liver Disease (NAFLD) Showcase

This animation demonstrates non-alcoholic fatty liver disease which is the most common form of liver disease caused by obesity and diabetes. Non-alcoholic fatty liver disease is the accumulation of fat in the liver cells also known as steatosis. Non-alcoholic steatohepatitis (NASH) causes inflammation and damage to liver cells that may lead to scarring or fibrosis. Non-alcoholic fatty liver disease is a silent condition that does not show symptoms until the patient develops advanced liver disease, Cirrhosis. Diagnosis of non-alcoholic fatty liver disease can be by ultrasound or blood test but ultimately a specialized liver biopsy is needed. Non-alcoholic fatty liver disease may be reversed by weight loss. This video illustration exhibits ground-breaking technology that can be used for marketing and education.

Partial Denture Replacement Implant Showcase

This animation highlights a removable, flexible, partial denture replacement implant that is economical and comfortable. These partial dentures feature no metal clasps which ultimately allows distribution of forces to stimulate & preserve the jawbone, keeping it healthy & strong. This piece is an excellent marketing tool as it discusses the product and its benefits.

Molar Implant System

This video showcases a molar implant system. It succinctly describes its methodology of use. This piece is an excellent example of how animation can be used for both training and educational purposes.

Cold Atmospheric Plasma Device

This stunning, 3D animation highlights an innovative, ultra-portable and easily applied cold atmospheric plasma device that effectively harnesses plasma vibronics to induce healing and hygiene at a cellular-level. The power of plasma has been found to address challenges in healthcare, hygiene, hydration and hydroponics. This piece is an outstanding example of how animation can be used in both education and marketing.

Melatonin Drug Mechanism of Action Showcase

Fruit thinning in apples

This animation depicts a state-of-the-art formulation of a plant growth regulator. The compound, a cytokinin, is shown chemically thinning apples and pears allowing growers to adjusts crop load, resulting in the highest returns per hectare, and ensuring good return bloom. This is a great example of how we can help agricultural technology companies explain their unique product mechanism.

The Endocannabinoid System

This animation explains the differences between CBD and THC and their respective effects on neurological pathways. This project is a great example of our domain experience in the rapidly evolving cannabinoid therapeutic space.

Cell Growth Equipment VR Experience

Laser treatment to vaporize floaters

Journey of a Cell

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